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  • AZD2858

    • AZD-2858,AZD 2858
    货号: abs810773
    CAS号: 486424-20-8
    分子式: C21H23N7O3S
    分子量: 453.52
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810773-5mg 1-2周 ¥858.00
    - +
    abs810773-10mg 1-2周 ¥1268.00
    - +
    abs810773-50mg 1-2周 ¥4618.00
    - +
    abs810773-100mg 1-2周 ¥8964.00
    - +
    大包装询价
    产品描述
    描述

    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    AZD-2858,AZD 2858
    外观
    Powder
    可溶性/溶解性
    DMSO :7 mg/mL (15.43 mM)
    生物活性
    靶点
    GSK-3
    In vitro(体外研究)
    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway. AZD2858 treatment (1 μM, 12 h) on primary isolated human osteoblast-like cells results in a 3-fold increase of β-catenin levels. AZD2858 causes β-catenin stabilisation in human and rat mesenchymal stem cells, stimulates hADSC commitment towards osteoblasts and osteogenic mineralisation in vitro.
    In vivo(体内研究)
    In rats, oral AZD2858 treatment causes a dose-dependent increase in trabecular bone mass compared to control after a two-week treatment with a maximum effect at a dose of 20 mg/kg once daily (total BMC: 172% of control). A small but significant effect is also seen at cortical sites (total BMC: 111% of control). AZD285 treatment (30 μmol/kg) on rats daily for up to 3 weeks shows an increase in both mineral density (of 28% at 2 weeks and 38% at 3 weeks) and mineral content (of 81% at 2 weeks and 93% at 3 weeks) in the calluses. AZD285 treatment makes the fractures heals more rapidly, with a bony callus without an obvious endochondral component. AZD2858 produces time-dependent changes in serum bone turnover biomarkers and increases bone mass over 28 days exposure in rats. After 7 days, AZD2858 increases the bone formation biomarker P1NP, and reduces the resorption biomarker TRAcP-5b, indicating increased bone anabolism and reduced resorption in rats.
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