AZ31
- AZ-31；AZ 31
货号： abs811992
| 货号-规格 | 货期 | 价格 | 数量 |
| abs811992-5mg | 1-2周 | ￥1268.00 | - + |
| abs811992-25mg | 1-2周 | ￥4025.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ). | |
| 纯度 | ＞98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | AZ-31；AZ 31 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO ：53 mg/mL (126.04 mM) | |
| 生物活性 | ||
| 靶点 | ATM | |
| In vitro(体外研究) | Antitumor effects of AZ31 + SN38 are cytostatic rather than cytotoxic. | |
| In vivo(体内研究) | Pharmacokinetic investigation of AZ31 as a single agent and in combination with irinotecan revealed that plasma concentrations of AZ31 were highest 1-hour after administration followed by a stepwise decrease at 3, 6 and 16 hour in the combination sensitive CRC098. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
