AZ31
- AZ-31;AZ 31
货号: abs811992
货号-规格 | 货期 | 价格 | 数量 |
abs811992-5mg | 1-2周 | ¥1268.00 | - + |
abs811992-25mg | 1-2周 | ¥4025.00 | - + |

产品描述 | ||
描述 | AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ). | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | AZ-31;AZ 31 | |
外观 | Powder | |
可溶性/溶解性 | DMSO :53 mg/mL (126.04 mM) | |
生物活性 | ||
靶点 | ATM | |
In vitro(体外研究) | Antitumor effects of AZ31 + SN38 are cytostatic rather than cytotoxic. | |
In vivo(体内研究) | Pharmacokinetic investigation of AZ31 as a single agent and in combination with irinotecan revealed that plasma concentrations of AZ31 were highest 1-hour after administration followed by a stepwise decrease at 3, 6 and 16 hour in the combination sensitive CRC098. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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