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  • AVE-3085
  • 货号: abs822142
    CAS号: 450348-85-3
    分子式: C17H13F2NO3
    分子量: 317.29
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs822142-1mg 4周 ¥1260.00
    - +
    abs822142-5mg 4周 ¥2520.00
    - +
    大包装询价
    产品描述
    描述
    AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    基本信息
    可溶性/溶解性
    DMSO*
    生物活性
    In vitro(体外研究)
    Pre-incubation with AVE3085 restores the bradykinin-induced relaxation, reverses the decrease of p-eNOSSer1177, and loares the level of p-eNOSThr495 and nitrotyrosine. NO release in response to bradykinin is significantly reduced by ADMA and such reduction is restored by AVE3085. AVE3085 also prevents the elevation of O2.− and ONOO− levels in coronary arteries exposed to ADMA. AVE3085 (10 μM) markedly increases ACh-induced relaxations in SHR aortae without affecting those in WKY aortae, and also increases the eNOS expression in WKY aortae.
    In vivo(体内研究)
    Pre-incubation with AVE3085 restores the bradykinin-induced relaxation, reverses the decrease of p-eNOSSer1177, and loares the level of p-eNOSThr495 and nitrotyrosine. NO release in response to bradykinin is significantly reduced by ADMA and such reduction is restored by AVE3085. AVE3085 also prevents the elevation of O2.− and ONOO− levels in coronary arteries exposed to ADMA. AVE3085 (10 μM) markedly increases ACh-induced relaxations in SHR aortae without affecting those in WKY aortae, and also increases the eNOS expression in WKY aortae.
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