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  • Atropine sulfate monohydrate

    • 硫酸阿托品一水合物
    货号: abs816649
    CAS号: 5908-99-6
    分子式: C34H46N2O6·H2SO4·H2O
    分子量: 694.83
    产品说明书
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    货号-规格 货期 价格 数量
    abs816649-50mg 1-2周 ¥309.00
    - +
    abs816649-100mg 1-2周 ¥497.00
    - +
    abs816649-200mg 1-2周 ¥882.00
    - +
    大包装询价
    产品描述
    描述

    Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    硫酸阿托品一水合物
    外观
    白色结晶性粉末
    可溶性/溶解性
    DMSO : 128 mg/mL (184.2 mM)

    Ethanol : 128 mg/mL (184.2 mM)

    Water : 127 mg/mL (182.8 mM)
    生物活性
    靶点
    mAChR
    In vitro(体外研究)
    Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina.
    In vivo(体内研究)
    Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%).
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    参考文献
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