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  • ATN-161 trifluoroacetate salt
    货号: abs818572
    CAS号: 904763-27-5
    分子式: C25H36F3N9O10S
    分子量: 711.67
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    货号-规格 货期 价格 数量
    abs818572-2mg 1-2周 ¥1764.00
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    abs818572-5mg 1-2周 ¥2646.00
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    大包装询价
    产品描述
    描述
    ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: < 7.3 mg/mL
    生物活性
    靶点
    Integrin
    In vitro(体外研究)
    The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p. ATN-161 inhibites VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. ATN-161 decreases the number of cells migrating in response to VEGF in a dose-dependent manner starting at 100 nM (P.
    In vivo(体内研究)
    The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density. Injection of ATN-161 after laser photocoagulation inhibits choroidal neovascularization (CNV) leakage and neovascularization to an extent similar to AF564.
    参考文献
    参考文献
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