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  • AT6
    货号: abs821574
    CAS号: 2098836-50-9
    分子式: C48H58ClN9O7S3
    分子量: 1004.68
    产品说明书
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    货号-规格 货期 价格 数量
    abs821574-5mg 4周 ¥7277.00
    - +
    abs821574-25mg 4周 ¥21168.00
    - +
    大包装询价
    产品描述
    描述
    AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO*
    生物活性
    In vitro(体外研究)
    PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells.
    In vivo(体内研究)
    PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells.
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    • 实验方法 实验条件
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