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  • AR-A014418

    • AR 0133418;GSK 3β inhibitor VIII;AR 014418
    货号: abs810578
    CAS号: 487021-52-3
    分子式: C12H12N4O4S
    分子量: 308.31
    产品说明书
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    货号-规格 货期 价格 数量
    abs810578-5mg 现货 ¥548.00
    - +
    abs810578-10mg 现货 ¥918.00
    - +
    abs810578-50mg 现货 ¥2342.00
    - +
    abs810578-100mg 现货 ¥4216.00
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    大包装询价
    产品描述
    描述

    AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    AR 0133418;GSK 3β inhibitor VIII;AR 014418
    外观
    Powder
    可溶性/溶解性
    DMSO : 30.8 mg/mL (100 mM)

    Ethanol : 1.5 mg/mL (5 mM)
    生物活性
    靶点
    GSK-3β ,GSK-3β
    In vitro(体外研究)
    AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in 3T3 fibroblasts expressing human four-repeat tau protein with IC50 of 2.7 μM, and protects cultured N2A cells from death induced by blocking PI3K/PKB pathway. In hippocampal slices, AR-A014418 inhibits neurodegeneration mediated by beta-amyloid peptide. While in NGP and SH-5Y-SY cells, AR-A014418 reduces neuroendocrine markers and suppresses neuroblastoma cell growth.
    In vivo(体内研究)
    In ALS mouse model with the G93A mutant human SOD1, AR-A014418 (0-4 mg/kg, i.p.) delays the onset of symptoms, improves motor activity, slows down disease progression, and postpons the endpoint of the disease. In addition, AR-A014418 produces inhibition effect on acetic acid- and formalin-induced nociception in mice by modulating NMDA and metabotropic receptor signaling as well as TNF-α and IL-1β transmission in the spinal cord.
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