AR-A014418
- AR 0133418;GSK 3β inhibitor VIII;AR 014418
货号: abs810578
货号-规格 | 货期 | 价格 | 数量 |
abs810578-5mg | 现货 | ¥548.00 | - + |
abs810578-10mg | 现货 | ¥918.00 | - + |
abs810578-50mg | 现货 | ¥2342.00 | - + |
abs810578-100mg | 现货 | ¥4216.00 | - + |

产品描述 | ||
描述 | AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | AR 0133418;GSK 3β inhibitor VIII;AR 014418 | |
外观 | Powder | |
可溶性/溶解性 | DMSO : 30.8 mg/mL (100 mM) Ethanol : 1.5 mg/mL (5 mM) | |
生物活性 | ||
靶点 | GSK-3β ,GSK-3β | |
In vitro(体外研究) | AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in 3T3 fibroblasts expressing human four-repeat tau protein with IC50 of 2.7 μM, and protects cultured N2A cells from death induced by blocking PI3K/PKB pathway. In hippocampal slices, AR-A014418 inhibits neurodegeneration mediated by beta-amyloid peptide. While in NGP and SH-5Y-SY cells, AR-A014418 reduces neuroendocrine markers and suppresses neuroblastoma cell growth. | |
In vivo(体内研究) | In ALS mouse model with the G93A mutant human SOD1, AR-A014418 (0-4 mg/kg, i.p.) delays the onset of symptoms, improves motor activity, slows down disease progression, and postpons the endpoint of the disease. In addition, AR-A014418 produces inhibition effect on acetic acid- and formalin-induced nociception in mice by modulating NMDA and metabotropic receptor signaling as well as TNF-α and IL-1β transmission in the spinal cord. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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