APX-115
- Ewha 18278；APX 115；APX115
货号： abs819699
| 货号-规格 | 货期 | 价格 | 数量 |
| abs819699-5mg | 1-2周 | ￥2363.00 | - + |
| abs819699-25mg | 1-2周 | ￥5933.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury. | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | Ewha 18278；APX 115；APX115 | |
| 可溶性/溶解性 | DMSO : ≥ 250 mg/mL (791.64 mM) | |
| 生物活性 | ||
| In vitro(体外研究) | APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. | |
| In vivo(体内研究) | APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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