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  • Aprotinin
    • 抑肽酶
    货号: abs816442
    CAS号: 9087-70-1
    分子式: C284H432N84O79S7
    分子量: 6511.48
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816442-10mg 现货 ¥509.00
    - +
    abs816442-25mg 1-2周 ¥992.00
    - +
    abs816442-50mg 1-2周 ¥1874.00
    - +
    abs816442-100mg 1-2周 ¥3262.00
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    大包装询价
    产品描述
    描述

    Aprotinin is a competitive serine protease inhibitor. Aprotinin reversibly binds to and blocks the enzymatic active site. Aprotinin inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin.

    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    抑肽酶
    外观
    白色粉末
    可溶性/溶解性
    Water :100 mg/mL (15.36 mM)
    生物活性
    靶点
    Chymotrypsin-like proteasome,kallikrein,Trypsin,trypsinogen
    In vitro(体外研究)
    Aprotinin is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. In cell biology, aprotinin is used as an enzyme inhibitor to prevent protein degradation during lysis or homogenization of cells and tissues. In the presence of aprotinin, the fibrinolytic activity is inhibited concentration dependently and the coagulation time is prolonged. Aprotinin is an effective inhibitor of the contact (intrinsic) coagulation pathway in vitro.
    In vivo(体内研究)
    Aprotinin inhibits clot lysis in vitro as well as rat-tail bleeding time in vivo and prolongs coagulation time in human plasma. In a rat arteriovenous shunt model, aprotinin reduces thrombus weight.
    参考文献
    参考文献
    Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
    Reichel CA, et al. PLoS One. 2011 Feb 22;6(2):e17229. PMID: 21364954.
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