Apocynin
- 4'-Hydroxy-3'-methoxyacetophenone; acetovanillone
货号: abs819572
货号-规格 | 货期 | 价格 | 数量 |
abs819572-1g | 现货 | ¥375.00 | - + |
abs819572-5g | 现货 | ¥827.00 | - + |

产品描述 | ||
描述 | Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. | |
应用 | A methoxy-substituted catechol commonly used as an inhibitor of NADPH oxidase | |
纯度 | ≥98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 4'-Hydroxy-3'-methoxyacetophenone; acetovanillone | |
外观 | white crystalline powder | |
可溶性/溶解性 | DMSO : 16.6 mg/mL (100 mM) Ethanol : 16.6 mg/mL (100 mM) | |
生物活性 | ||
靶点 | NADPH-oxidase | |
In vitro(体外研究) | Apocynin is a naturally occurring methoxy-substituted catechol used as an inhibitor of NADPH-oxidase. Apocynin prevents serine phosphorylation of p47phox and blocks its association with gp91phox, thus blunting NADPH oxidase activation. Apocynin can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production. | |
In vivo(体内研究) | Apocynin has anti-inflammatory activity in a variety of cell and animal models of inflammation. Apocynin attenuates the TNF-α and IL-1β production and iNOS expression in the lung of carrageenan-treated mice. Apocynin exerts beneficial effects in a mice model of spinal cord injury. Apocynin reduces (1) the degree of spinal cord damage, (2) neutrophils infiltration, (3) ICAM-1 and P-selectin expression, (4) PAR and nitrotyrosine formation, (5) IκB-α degradation, (6) NF-κB activation, (7) pro-inflammatory cytokines production (TNF-α and IL-1β), (8) apoptosis (TUNEL staining, FAS ligand expression, Bax and Bcl-2 expression) and (9) MAPK activation (P-38 and phospho-JNK). LD50: Mice 9g/kg (i.g.). | |
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- 实验方法 实验条件
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