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  • Apocynin

    • 4'-Hydroxy-3'-methoxyacetophenone; acetovanillone
    货号: abs819572
    CAS号: 498-02-2
    分子式: C9H10O3
    分子量: 166.17
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    货号-规格 货期 价格 数量
    abs819572-1g 现货 ¥375.00
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    abs819572-5g 现货 ¥827.00
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    大包装询价
    产品描述
    描述

    Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

    应用
    A methoxy-substituted catechol commonly used as an inhibitor of NADPH oxidase
    纯度
    ≥98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    4'-Hydroxy-3'-methoxyacetophenone; acetovanillone
    外观
    white crystalline powder
    可溶性/溶解性
    DMSO : 16.6 mg/mL (100 mM)

    Ethanol : 16.6 mg/mL (100 mM)
    生物活性
    靶点
    NADPH-oxidase
    In vitro(体外研究)
    Apocynin is a naturally occurring methoxy-substituted catechol used as an inhibitor of NADPH-oxidase. Apocynin prevents serine phosphorylation of p47phox and blocks its association with gp91phox, thus blunting NADPH oxidase activation. Apocynin can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.
    In vivo(体内研究)
    Apocynin has anti-inflammatory activity in a variety of cell and animal models of inflammation. Apocynin attenuates the TNF-α and IL-1β production and iNOS expression in the lung of carrageenan-treated mice. Apocynin exerts beneficial effects in a mice model of spinal cord injury. Apocynin reduces (1) the degree of spinal cord damage, (2) neutrophils infiltration, (3) ICAM-1 and P-selectin expression, (4) PAR and nitrotyrosine formation, (5) IκB-α degradation, (6) NF-κB activation, (7) pro-inflammatory cytokines production (TNF-α and IL-1β), (8) apoptosis (TUNEL staining, FAS ligand expression, Bax and Bcl-2 expression) and (9) MAPK activation (P-38 and phospho-JNK). LD50: Mice 9g/kg (i.g.).
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