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  • API-1
    • 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
    货号: abs819448
    CAS号: 36707-00-3
    分子式: C13H15N5O6
    分子量: 337.29
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs819448-5mg 4周 ¥2040.00
    - +
    abs819448-10mg 4周 ¥3694.00
    - +
    大包装询价
    产品描述
    描述

    API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. It reduces cell proliferation in various cancer cell lines, induces apoptosis, and, at a dose of 10 mg/kg per day, decreases tumor growth in a mouse xenograft model. API-1 inhibition of Akt leads to proteasomal degradation of the downstream mediator Mcl-1. Likely independent of Akt binding, API-1 inhibits cell growth (IC50s = 2-5 uM) and induces apoptosis in non-small cell lung and head and neck squamous cancer (NSCLC and HNSCC) cell lines with concomitant increases in caspase-3, -8, and -9 cleavage. It reduces the levels of cellular FLICE-inhibitory protein (c-FLIP), an important regulator of apoptosis, through ubiquitin- and proteasome-mediated degradation. It also has a synergistic effect on apoptosis in combination with TRAIL/APO-2L.The information regarding the reduction in phosphorylated Akt levels, IC50 value, translocation, cell proliferation, and xenograft tumor growth was drawn from a paper that has been retracted; however, the information specified in the retraction statement has not been included.

    纯度
    98%
    储存/保存方法
    Store at -20° C
    形态
    Solid
    基本信息
    别名
    4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
    外观
    white to beige powder
    可溶性/溶解性
    Soluble in DMSO (100 mM).
    生物活性
    靶点
    Akt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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