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  • AP20187
    • AP 20187;B/B Homodimerizer
    货号: abs818602
    CAS号: 195514-80-8
    分子式: C82H107N5O20
    分子量: 1482.75
    产品说明书
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    货号-规格 货期 价格 数量
    abs818602-10mg 1-2周 ¥5600.00
    - +
    abs818602-50mg 1-2周 ¥8200.00
    - +
    大包装询价
    产品描述
    描述
    AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    AP 20187;B/B Homodimerizer
    可溶性/溶解性
    DMSO : ≥ 57 mg/mL (38.44 mM)
    生物活性
    靶点
    Others
    In vitro(体外研究)
    When LNCaP cells are treated with AP20187 (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.
    In vivo(体内研究)
    Real-time PCR analysis shows that AP20187 (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice.
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    • 实验方法 实验条件
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