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  • Antazoline hydrochloride
    • 盐酸安他唑啉;Phenazoline hydrochloride
    货号: abs813486
    CAS号: 2508-72-7
    分子式: C17H19N3.HCl
    分子量: 301.81
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    货号-规格 货期 价格 数量
    abs813486-100mg 1-2周 ¥330.00
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    产品描述
    描述

    Antazoline hydrochloride is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.On insulin secretion, the two imidazolines (antazoline and efaroxan), induced a concentration-dependent response.Antazoline being 10 times more potent than efaroxan. In contrast, idazoxan, a blocker of imidazoline I1 sites,when the concentrations up to 30 microM, it antagonized the insulin response to 10 microM efaroxan (IC50 approximately equal to 14 +/- 2 microM) without affecting that to 3 microM tolbutamide.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    盐酸安他唑啉;Phenazoline hydrochloride
    外观
    白色结晶粉末
    可溶性/溶解性
    Ethanol :4 mg/mL (13.25 mM)

    DMSO :14 mg/mL (46.38 mM)

    Water :14 mg/mL (46.38 mM)
    生物活性
    靶点
    H1 receptor
    In vitro(体外研究)
    Antazoline (30 microM) decreases NMDA-mediated neurotoxicity and also blocked the NMDA current with voltage-dependent and fast-reversible action (inhibition by 85+/-3% at -60 mV)
    In vivo(体内研究)
    Antazoline is neuroprotective in vivo in the intra-pyriform pilocarpine-induced status epilepticus model.
    参考文献
    参考文献
    Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.
    Berdeu D, et al. Eur J Pharmacol. 1995 Feb 24;275(1):91-8. PMID: 7774667.
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