Antazoline hydrochloride
- 盐酸安他唑啉；Phenazoline hydrochloride
货号： abs813486
| 货号-规格 | 货期 | 价格 | 数量 |
| abs813486-100mg | 1-2周 | ￥330.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Antazoline hydrochloride is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.On insulin secretion, the two imidazolines (antazoline and efaroxan), induced a concentration-dependent response.Antazoline being 10 times more potent than efaroxan. In contrast, idazoxan, a blocker of imidazoline I1 sites,when the concentrations up to 30 microM, it antagonized the insulin response to 10 microM efaroxan (IC50 approximately equal to 14 +/- 2 microM) without affecting that to 3 microM tolbutamide. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | 盐酸安他唑啉；Phenazoline hydrochloride | |
| 外观 | 白色结晶粉末 | |
| 可溶性/溶解性 | Ethanol ：4 mg/mL (13.25 mM) DMSO ：14 mg/mL (46.38 mM) Water ：14 mg/mL (46.38 mM) | |
| 生物活性 | ||
| 靶点 | H1 receptor | |
| In vitro(体外研究) | Antazoline (30 microM) decreases NMDA-mediated neurotoxicity and also blocked the NMDA current with voltage-dependent and fast-reversible action (inhibition by 85+/-3% at -60 mV) | |
| In vivo(体内研究) | Antazoline is neuroprotective in vivo in the intra-pyriform pilocarpine-induced status epilepticus model. | |
| 参考文献 | ||
| 参考文献 | Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Berdeu D,et al. Eur J Pharmacol. 1995 Feb 24;275(1):91-8. PMID: 77746 䔸Żᩄ 族痛 | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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