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  • Anastrozole
    • 阿那曲唑;阿纳托唑;ZD1033
    货号: abs816656
    CAS号: 120511-73-1
    分子式: C17H19N5
    分子量: 293.37
    产品说明书
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    货号-规格 货期 价格 数量
    abs816656-10mg 现货 ¥497.00
    - +
    abs816656-50mg 现货 ¥1489.00
    - +
    abs816656-100mg 现货 ¥2150.00
    - +
    abs816656-500mg 1-2周 ¥4907.00
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    大包装询价
    产品描述
    描述

    Anastrozole(ZD1033) is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    阿那曲唑;阿纳托唑;ZD1033
    外观
    白色或类白色结晶性粉末
    可溶性/溶解性
    DMSO : 29.3 mg/mL (100 mM)

    Ethanol : 29.3 mg/mL (100 mM)
    生物活性
    靶点
    Aromatase
    In vitro(体外研究)
    Anastrozole has high intrinsic potency in vitro and inhibits human placental aromatase with an IC50 of 15 nM. Anastrozole it is 200 times as potent as AG, twice as potent as 4-OHA and one third as potent as fadrozole. . Anastrozole inhibits aromatase by binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones.
    In vivo(体内研究)
    Anastrozole (0.1 mg/kg) given orally to mature rats on Day 2 or 3 of the estrous cycle, blocked ovulation in mature females; in pubertal rats, the same dose given for 3 days completely blocks androstenedione-stimulated uterine development. These effects may be attributes to inhibition of the normal preovulatory rise in ovarian follicular estrogen synthesis in mature females and to inhibition of metabolism of the exogenous androstenedione by the immature ovary in prepubertal females. Twice-daily administration of >9.1 mg/kg of Anastrozole given orally to male pigtailed monkeys inhibits peripheral aromatase, thereby reducing circulating estradiol concentrations by 50% to 60%.
    参考文献
    参考文献
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