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  • AN2/AVex-73 hydrochloride

    • AE-37 hydrochloride
    货号: abs813126
    CAS号: 195615-84-0
    分子式: C19H24ClNO
    分子量: 317.860
    产品说明书
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    货号-规格 货期 价格 数量
    abs813126-5mg 1-2周 ¥1402.00
    - +
    abs813126-10mg 1-2周 ¥2226.00
    - +
    abs813126-50mg 1-2周 ¥7586.00
    - +
    大包装询价
    产品描述
    描述

    AVex-73 hydrochloride 是一个 Sigma-1 受体激动剂,其 IC50 值为 860 nM。

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    AE-37 hydrochloride
    可溶性/溶解性
    DMSO :37.5 mg/mL
    生物活性
    靶点
    Sigma Receptor
    In vivo(体内研究)
    The pre-administration of AVex-73 hydrochloride (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with AVex-73 hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The AVex-73 hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by AVex-73 hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections,AVex-73 hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The AVex-73 hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested.
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