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  • Amlexanox
    • 氨来呫诺;AA673;Amoxanox;CHX3673
    货号: abs817313
    CAS号: 68302-57-8
    分子式: C15H14N2O4
    分子量: 298.29
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs817313-10mg 1-2周 ¥507.00
    - +
    abs817313-20mg 1-2周 ¥827.00
    - +
    abs817313-50mg 1-2周 ¥931.00
    - +
    abs817313-100mg 1-2周 ¥1148.00
    - +
    大包装询价
    产品描述
    描述

    Amlexanox (AA673; CHX3673) is a specific inhibitor of IKKε and TBK1; inhibition of IKKε and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1–2 μM.

    纯度
    99%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    氨来呫诺;AA673;Amoxanox;CHX3673
    外观
    白色结晶性粉末
    可溶性/溶解性
    DMSO : ≥36 mg/mL
    生物活性
    靶点
    TBK1 ,IKK-ε
    In vitro(体外研究)
    Dose-response relationship of amlexanox inhibition of IKK-ɛ and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1-2 μM. Amlexanox also blocks the activity of TBK1 at approximately the same concentrations but has no effect on IKK-α or IKK-β and at these concentrations do not block any other kinases from a broad panel representing most kinase families. Inhibition of IKK-ɛ or TBK1 by amlexanox is competitive for its substrate ATP, indicating that it interacts with the enzymes in the ATP-binding site. Amlexanox increases the phosphorylation of TBK1 at Ser172 in 3T3-L1 adipocytes and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKK-ɛ and TBK1.
    In vivo(体内研究)
    Treatment of obese mice with amlexanox elevates energy expenditure through increased thermogenesis, producing weight loss, improves insulin sensitivity and decreases steatosis.
    参考文献
    参考文献
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