- 氨来呫诺；AA673；Amoxanox；CHX3673
货号： abs817313
| 货号-规格 | 货期 | 价格 | 数量 |
| abs817313-10mg | 1-2周 | ￥507.00 | - + |
| abs817313-20mg | 1-2周 | ￥827.00 | - + |
| abs817313-50mg | 1-2周 | ￥931.00 | - + |
| abs817313-100mg | 1-2周 | ￥1148.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Amlexanox (AA673; CHX3673) is a specific inhibitor of IKKε and TBK1; inhibition of IKKε and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1–2 μM. | |
| 纯度 | 99% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 别名 | 氨来呫诺；AA673；Amoxanox；CHX3673 | |
| 外观 | 白色结晶性粉末 | |
| 可溶性/溶解性 | DMSO : ≥36 mg/mL | |
| 生物活性 | ||
| 靶点 | TBK1 ,IKK-ε | |
| In vitro(体外研究) | Dose-response relationship of amlexanox inhibition of IKK-ɛ and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1-2 μM. Amlexanox also blocks the activity of TBK1 at approximately the same concentrations but has no effect on IKK-α or IKK-β and at these concentrations do not block any other kinases from a broad panel representing most kinase families. Inhibition of IKK-ɛ or TBK1 by amlexanox is competitive for its substrate ATP, indicating that it interacts with the enzymes in the ATP-binding site. Amlexanox increases the phosphorylation of TBK1 at Ser172 in 3T3-L1 adipocytes and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKK-ɛ and TBK1. | |
| In vivo(体内研究) | Treatment of obese mice with amlexanox elevates energy expenditure through increased thermogenesis, producing weight loss, improves insulin sensitivity and decreases steatosis. | |
| 参考文献 | ||
| 参考文献 | ||
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
