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  • ALS-8112

    货号: abs818536
    CAS号: 1445379-92-9
    分子式: C10H13ClFN3O4
    分子量: 293.68
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs818536-1mg 1-2周 ¥2646.00
    - +
    abs818536-5mg 1-2周 ¥6174.00
    - +
    大包装询价
    产品描述
    描述
    ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: ≥ 47 mg/mL
    生物活性
    靶点
    RSV
    In vitro(体外研究)
    The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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