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  • Almitrine mesylate

    • 甲磺酸阿米三嗪;Almitrine bismesylate;Almitrine bismethanesulfonate;Almitrine dimesylate
    货号: abs821881
    CAS号: 29608-49-9
    分子式: C28H37F2N7O6S2
    分子量: 669.76
    产品说明书
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    货号-规格 货期 价格 数量
    abs821881-10mg 1-2周 ¥794.00
    - +
    abs821881-50mg 1-2周 ¥1588.00
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    大包装询价
    产品描述
    描述
    Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    甲磺酸阿米三嗪;Almitrine bismesylate;Almitrine bismethanesulfonate;Almitrine dimesylate
    可溶性/溶解性
    DMSO : 100 mg/mL (149.31 mM; Need ultrasonic)
    生物活性
    靶点
    K+ channel
    In vitro(体外研究)
    Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability. The IC50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca2+-dependent component of K+ currents in rat chemoreceptor cells.
    In vivo(体内研究)
    Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio.
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    • 实验方法 实验条件
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