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  • Aleglitazar
  • 货号: abs818634
    CAS号: 475479-34-6
    分子式: C24H23NO5S
    分子量: 437.51
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    货号-规格 货期 价格 数量
    abs818634-5mg 1-2周 ¥4469.00
    - +
    abs818634-10mg 1-2周 ¥5767.00
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    产品描述
    描述
    Aleglitazar(R1439; RO-0728804) is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.IC50 Value: 2.8 nM(PPAR-α); 4.6 nM(PPAR-γ)Target: PPARα/γAleglitazar (R1439) is a dual peroxisome proliferator-activated receptor (PPAR) agonist, with affinity to PPARα and PPARγ. Aleglitazar is being developed for the treatment of type II diabetes; It is currently in phase III clinical trials. In preliminary clinical studies, Aleglitazar has been demonstrated to improve hyperglycemia and dyslipidemia in patients with type 2 diabetes mellitus. Aleglitazar has beneficial effects on both lipid and glucose parameters and may have a therapeutic role in modifying cardiovascular risk factors and improving glycemic control in patients with T2DM. Aleglitazar combines the lipid benefits of fibrates and the insulin-sensitizing benefits of thiazolidinediones.
    基本信息
    可溶性/溶解性
    10 mM in DMSO
    参考文献
    参考文献
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