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  • AL 8697

    • AL-8697;AL8697
    货号: abs814686
    CAS号: 1057394-06-5
    分子式: C21H21F3N4O
    分子量: 402.41
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    货号-规格 货期 价格 数量
    abs814686-10mg 4周 ¥7084.00
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    产品描述
    描述

    AL8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38 α inhibitor. It has the function of inhibiting the activity of P38 MAPK.[

    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    AL-8697;AL8697
    外观
    White solid
    可溶性/溶解性
    Soluble in DMSO > 10 mM
    生物活性
    靶点
    p38
    In vitro(体外研究)
    AL8697 function by the inhibition of P38 MAPK. It regulates a variety of cell activities related with P38 MAPK.
    In vivo(体内研究)
    In a rat adjuvant-induced arthritis model, AL8697 exhibited a good anti-inflammatory effect and induced leukocytosis and increased total plasma cholesterol, these properties were evidently at 10 mg/kg. In addition, AL8697 partially restored the platelet count. The complex profile for AL8697 in rat AIA (adjuvant-induced arthritis) is not observed in human RA (rheumatoid arthritis).
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