- AKTI-1/2
货号: abs810176
货号-规格 | 货期 | 价格 | 数量 |
abs810176-5mg | 1-2周 | ¥1298.00 | - + |
abs810176-10mg | 1-2周 | ¥2122.00 | - + |
abs810176-50mg | 1-2周 | ¥5418.00 | - + |
abs810176-100mg | 1-2周 | ¥7740.00 | - + |

产品描述 | ||
描述 | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
基本信息 | ||
别名 | AKTI-1/2 | |
外观 | 黄色粉末 | |
可溶性/溶解性 | DMSO : 11 mg/mL (20 mM), with gentle warming
| |
生物活性 | ||
靶点 | Akt1 ,Akt2 ,Akt3 | |
In vitro(体外研究) | In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. | |
In vivo(体内研究) | In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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