- AKTI-1/2
货号： abs810176
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810176-5mg | 1-2周 | ￥1298.00 | - + |
| abs810176-10mg | 1-2周 | ￥2122.00 | - + |
| abs810176-50mg | 1-2周 | ￥5418.00 | - + |
| abs810176-100mg | 1-2周 | ￥7740.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 别名 | AKTI-1/2 | |
| 外观 | 黄色粉末 | |
| 可溶性/溶解性 | DMSO : 11 mg/mL (20 mM), with gentle warming
| |
| 生物活性 | ||
| 靶点 | Akt1 ,Akt2 ,Akt3 | |
| In vitro(体外研究) | In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. | |
| In vivo(体内研究) | In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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李晓勇, 刘涛, 李建, 刘超, 刘宇宏
中国细胞生物学学报. 2020 Jan 01 ; 1
Certificate of Analysis(COA)
