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  • Akt Inhibitor VIII(Akti-1/2)
    • AKTI-1/2
    货号: abs810176
    CAS号: 612847-09-3
    分子式: C34H29N7O
    分子量: 551.64
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810176-5mg 1-2周 ¥1298.00
    - +
    abs810176-10mg 1-2周 ¥2122.00
    - +
    abs810176-50mg 1-2周 ¥5418.00
    - +
    abs810176-100mg 1-2周 ¥7740.00
    - +
    大包装询价
    产品描述
    描述

    Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    AKTI-1/2
    外观
    黄色粉末
    可溶性/溶解性
    DMSO : 11 mg/mL (20 mM), with gentle warming


    生物活性
    靶点
    Akt1 ,Akt2 ,Akt3
    In vitro(体外研究)
    In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis.
    In vivo(体内研究)
    In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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