- AGI 6780; AGI6780
货号: abs810589
货号-规格 | 货期 | 价格 | 数量 |
abs810589-5mg | 1-2周 | ¥876.00 | - + |
abs810589-10mg | 1-2周 | ¥1659.00 | - + |
abs810589-50mg | 1-2周 | ¥5334.00 | - + |
abs810589-100mg | 1-2周 | ¥9169.00 | - + |

产品描述 | ||
描述 | AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM). | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. | |
基本信息 | ||
别名 | AGI 6780; AGI6780 | |
外观 | Powder | |
可溶性/溶解性 | DMSO 96 mg/mL (199.37 mM) Ethanol 96 mg/mL (199.37 mM) | |
生物活性 | ||
靶点 | IDH2 R140Q mutant | |
In vitro(体外研究) | AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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