- AGI 6780; AGI6780
货号： abs810589
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810589-5mg | 1-2周 | ￥876.00 | - + |
| abs810589-10mg | 1-2周 | ￥1659.00 | - + |
| abs810589-50mg | 1-2周 | ￥5334.00 | - + |
| abs810589-100mg | 1-2周 | ￥9169.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM). | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months. | |
| 基本信息 | ||
| 别名 | AGI 6780; AGI6780 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO 96 mg/mL (199.37 mM) Ethanol 96 mg/mL (199.37 mM) | |
| 生物活性 | ||
| 靶点 | IDH2 R140Q mutant | |
| In vitro(体外研究) | AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 提示： 尊敬的客户您好，如果您对我们的产品有什么疑问或想要了解的，可以点击“我要提问”按钮填写您的疑问。
提交不成功？请联系info@absin.cn。
Certificate of Analysis(COA)
