AG 490
爱闪购- AG 490; Tyrphostin AG 490; AG490; Zinc02557947;AG-490 (Tyrphostin B42)
货号: abs810014
货号-规格 | 货期 | 价格 | 数量 |
abs810014-5mg | 现货 | ¥221.00 | - + |
abs810014-10mg | 现货 | ¥331.00 | - + |
abs810014-25mg | 现货 | - + | |
abs810014-50mg | 现货 | ¥1042.00 | - + |

产品描述 | ||
描述 | AG-490 (Tyrphostin B42)是一种EGFR抑制剂,在无细胞试验中IC50为0.1μM,作用于EGFR比作用于ErbB2选择性高135倍,对JAK2也有抑制作用,对Lck,Lyn,Btk,Syk和Src没有抑制活性。 | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | AG 490; Tyrphostin AG 490; AG490; Zinc02557947;AG-490 (Tyrphostin B42) | |
外观 | yellow solid | |
可溶性/溶解性 | DMSO:58 mg/mL (197.07 mM) Ethanol:6 mg/mL (20.38 mM) | |
生物活性 | ||
靶点 | EGFR | |
In vivo(体内研究) | AG490 significantly inhibits the development of type 1 diabetes (T1D) (p = 0.02, p = 0.005; at two different time points). Monotherapy of newly diagnosed diabetic NOD mice with AG490 (1 mg/mouse) markedly results in disease remission in treated animals (n=23) in comparision to the absolute inability (0%; 0/10, p=0.003, Log-rank test) of DMSO and sustained eugluycemia is maintained for several months following drug withdrawal. AG490 (1-10 µg) significantly attenuates ʎ-carrageenan-induced thermal hyperalgesia in a dose-dependent manner. AG490 also reduces mechanical hyperalgesia. | |
参考文献 | ||
参考文献 | [1] Gazit A, et al. J Med Chem, 1991, 34(6), 1896-1907.
[2] Meydan N, et al. Nature, 1996, 379(6566), 645-648. [3] Nielsen M, et al. Proc Natl Acad Sci U S A, 1997, 94(13), 6764-6769. [4] Kirken RA, et al. J Leukoc Biol, 1999, 65(6), 891-899. [5] Sun X, et al. Blood, 2001, 97(7), 2008-2015. [6] Burdelya L, et al. Mol Cancer Ther, 2002, 1(11), 893-899. [7] Samanta AK, et al. Cancer Res, 2006, 66(13), 6468-6472. [8] Abe M, et al. Int Immunopharmacol, 2009, 9(7-8), 870-877. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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