AF-353
- AF 353;Ro-4
货号: abs817400
货号-规格 | 货期 | 价格 | 数量 |
abs817400-5mg | 现货 | ¥850.00 | - + |
abs817400-10mg | 现货 | ¥1450.00 | - + |
abs817400-50mg | 现货 | ¥4150.00 | - + |

产品描述 | ||
描述 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | AF 353;Ro-4 | |
可溶性/溶解性 | DMSO : 100 mg/mL (249.87 mM; Need ultrasonic) | |
生物活性 | ||
靶点 | P2X3 | |
In vitro(体外研究) | AF-353 (Ro-4) is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. AF-353 (Ro-4) also blocks human P2X2/3 channel function with marginally reduced potency with a p50 of 7.3. | |
In vivo(体内研究) | AF-353 (Ro-4) does not compromise oxygen levels or cardiac function. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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