Acetylcysteine

＞98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

乙酰半胱氨酸；N-Acetyl-L-cysteine；LNAC；NAC

白色结晶性粉末

DMSO : 31 mg/mL (190 mM)
Ethanol : 31 mg/mL (190 mM)
Water : 30 mg/mL (183.8 mM)

ROS/ROS1,TNF-α

N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism.

N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.

[1] Alvirez-Freites EJ, et al. Antimicrob Agents Chemother, 2002, 46(4), 1022-1025.
[2] Tsai, J.C., et al. 1996. J. Biol. Chem. 271: 3667-3670.
[3] Tirouvanziam, R., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 4628-4633.
[4] Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161: 1907-1911.