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  • Acetaminophen

    • 对乙酰氨基酚;Paracetamol; 4'-Hydroxyacetanilide;4-Acetamidophenol;APAP
    货号: abs815915
    CAS号: 103-90-2
    分子式: C8H9NO2
    分子量: 151.16
    产品说明书
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    货号-规格 货期 价格 数量
    abs815915-500mg 现货 ¥264.00
    - +
    abs815915-5g 现货 ¥488.00
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    大包装询价
    产品描述
    描述

    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor.

    纯度
    99%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    对乙酰氨基酚;Paracetamol; 4'-Hydroxyacetanilide;4-Acetamidophenol;APAP
    外观
    White powder
    可溶性/溶解性
    DMSO :15.1 mg/mL (100 mM)
    Ethanol :15.1 mg/mL (100 mM)
    生物活性
    靶点
    Endogenous Metabolite
    In vitro(体外研究)
    In vitro, acetaminophen elicites a 4.4-fold selectivity toward COX-2 inhibition (IC50 113.7 μM for COX-1; IC50 25.8 μM for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions are 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remaine above the in vitro IC50 for COX-2 for at least 5 h postadministration. Ex vivo IC50 values (COX-1: 105.2 μM; COX-2: 26.3 μM) of acetaminophen compared favorably with its in vitro IC50 values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function is not achieved.MTT assay shows that Acetaminophen (APAP) in a dose of 50 mM significantly (p.
    In vivo(体内研究)
    Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p.
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    • 实验方法 实验条件
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