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  • Ac-DEVD-CHO
  • Caspase-3 Inhibitor I;N-Ac-Asp-Glu-Val-Asp-CHO;Acetyl-aspartyl-glutamyl-valyl-aspartal
  • 货号: abs811858
    CAS号: 169332-60-9
    分子式: C20H30N4O11
    分子量: 502.5
    产品说明书
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    货号-规格 货期 价格 数量
    abs811858-5mg 1-2周 ¥2830.00
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    大包装询价
    产品描述
    描述

    Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    Caspase-3 Inhibitor I;N-Ac-Asp-Glu-Val-Asp-CHO;Acetyl-aspartyl-glutamyl-valyl-aspartal
    外观
    white powder
    可溶性/溶解性
    H2O : ≥ 50 mg/mL (99.51 mM)mL
    生物活性
    靶点
    Caspase-3,caspase-8,caspase-7,caspase-10 ,Caspase-1
    In vitro(体外研究)
    Ac-DEVD-CHO is a potent inhibitor of caspase-3 (Ki = 230 pM). In contrast, caspase-2 cleaves the tetrapeptide substrate poorly and is only weakly inhibited by this aldehyde (Ki = 1.7 μM). Group III caspases are broadly inhibited by Ac-DEVD-CHO with Ki values ranging from 1 to 300 nM. Inhibition of caspase-3 by Ac-DEVD-CHO in isolated working-heart rat model significantly improves post-ischemic contractile recovery of stunned myocardium, even when given after the onset of ischemia. The mechanism(s) of protection by Ac-DEVD-CHO appear to be independent of apoptosis. Troponin I cleavage was not inhibited by Ac-DEVD-CHO.
    In vivo(体内研究)
    Ac-DEVD-CHO administered at the time of MI results in a 61% reduction in activated caspase-3 expression in cardiomyocytes (p. Ac-DEVD-CHO suppressed and/or delayed the progression of photoreceptor cell damage in rats and delays disease progression in rd gene-carring mice, which normally develop retinal degeneration early in life.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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