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  • ABT-751

    • E7010; E-7010; E 7010
    货号: abs810804
    CAS号: 141430-65-1
    分子式: C18H17N3O4S
    分子量: 371.41
    产品说明书
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    货号-规格 货期 价格 数量
    abs810804-5mg 现货 ¥545.00
    - +
    abs810804-10mg 现货 ¥880.00
    - +
    abs810804-50mg 现货 ¥3430.00
    - +
    abs810804-100mg 现货 ¥4700.00
    - +
    大包装询价
    产品描述
    描述

    ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    E7010; E-7010; E 7010
    外观
    Off white powder
    可溶性/溶解性
    DMSO : ≥ 48 mg/mL (129.24 mM)
    Ethanol :12 mg/mL (32.31 mM)
    生物活性
    靶点
    Microtubules
    In vitro(体外研究)
    ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751.
    In vivo(体内研究)
    In this Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU. In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively.
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    • 实验方法 实验条件
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