ABT-751
- E7010; E-7010; E 7010
货号: abs810804
货号-规格 | 货期 | 价格 | 数量 |
abs810804-5mg | 现货 | ¥545.00 | - + |
abs810804-10mg | 现货 | ¥880.00 | - + |
abs810804-50mg | 现货 | ¥3430.00 | - + |
abs810804-100mg | 现货 | ¥4700.00 | - + |

产品描述 | ||
描述 | ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | E7010; E-7010; E 7010 | |
外观 | Off white powder | |
可溶性/溶解性 | DMSO : ≥ 48 mg/mL (129.24 mM) Ethanol :12 mg/mL (32.31 mM) | |
生物活性 | ||
靶点 | Microtubules | |
In vitro(体外研究) | ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules and spares stable microtubules, accounting for the persistence of acetylated and detyrosinated α-tubulin positive polymerized tubules at the IC90 concentration of ABT-751. | |
In vivo(体内研究) | In this Calu-6 xenograft model, ABT-751 as a single agent at 100 and 75 mg/kg/day shows significant antitumor activity, while in combination with cisplatin, ABT-751 shows a dose-dependent enhancement in growth delay. In the HT-29 colon xenograft model, ABT-751 also shows significant antitumor activity as a single agent and produced a dose-dependent enhancement in growth delay In combination with 5-FU. In dogs with lymphoma, ABT-751 exhibits the dose-limiting toxicities that included vomiting, diarrhea, anorexia, or some combination of these with a maximum tolerated dose (MTD) of 350 mg/m2 PO q24h. Furthermore, the mean AUC and Cmax for ABT-751 at the MTD of 350 mg/m2 is 5.55 μg-hour/mL and 0.9 μg/mL, respectively. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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