A804598
- A 804598; A-804598
货号: abs812003
货号-规格 | 货期 | 价格 | 数量 |
abs812003-10mg | 1-2周 | ¥485.00 | - + |
abs812003-50mg | 1-2周 | ¥1455.00 | - + |

产品描述 | ||
描述 | A-804598是一个强的,竞争性,和选择性的P2X7受体拮抗剂,在大鼠,小鼠和体内的IC50分别是10 nM, 9 nM 和11 nM。 | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | A 804598; A-804598 | |
可溶性/溶解性 | DMSO: ≥ 32 mg/mL | |
生物活性 | ||
靶点 | rat P2X7R ,rat P2X7R ,human P2X7R | |
In vitro(体外研究) | A-804598 represents a structurally novel, competitive, and selective antagonist that has equivalent high affinity at rat (IC50 = 10 nM), mouse (IC50 = 9 nM) and human (IC50 = 11 nM) P2X7 receptors. A-804598 also potently blocks agonist stimulated release of IL-1β(IC50 of 8.5 nM) and Yo-Pro uptake (IC50 of 8.1 nM) from differentiated THP-1 cells that natively express human P2X7 receptors. Although A-840598 potently blocks P2X7 receptor activation, at concentrations up to 100 μM, it does not significantly reduce agonist-evoked changes in intracellular calcium concentrations mediated by a variety of other P2X and P2Y receptors. A-840598 shows weak or no activity for interating with a large array of G-protein-coupled receptors, enzymes, transporters, and ion channels (CEREP, Poitiers, France)(IC50 > 5-10 μM). | |
In vivo(体内研究) | Inhibition of P2X7 through the antagonist A-804598 in SOD1-G93A mice suppresses SQSTM1/p62 up-regulation in lumbar spinal cord. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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