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  • A1155463

    • A-1155463; A 1155463; A1155463.
    货号: abs814335
    CAS号: 1235034-55-5
    分子式: C35H32FN5O4S2
    分子量: 669.79
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs814335-50mg 4周 ¥3135.00
    - +
    abs814335-100mg 4周 ¥5017.00
    - +
    大包装询价
    产品描述
    描述
    A-1155463 is a highly potent and selective BCL-XL inhibitor.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    A-1155463; A 1155463; A1155463.
    外观
    Powder
    生物活性
    靶点
    BCL-XL
    In vitro(体外研究)
    A-1155463 disrupts BCL-XL-BIM but not BCL-2-BIM complexes in cells. A-1155463 kills BCL-XL-dependent Molt-4 cells (EC50=70 nM) but has no measurable cytotoxicity against BCL-2-dependent RS4;11 cells(EC50>5 mM). A-1155463 induces the hallmarks of apoptosis, as evidenced by the release of cytochrome c from mitochondria, caspase activation, and the accumulation of caspase-dependent sub-G0-G1 DNA content in BCL-XL-dependent H146 cells.
    In vivo(体内研究)
    Following a single 5 mg/kg IP dose of A-1155463 in nontumor bearing SCID-Beige mice, platelet counts fall dramatically as measured at 6 h postdose and then rebound to normal levels within 72 h. Daily Dosing at 5 mg/kg IP to SCID-Beige mice that had been inoculated with BCL-XL-dependent H146 tumor cells for 14 days causes a statistically significant inhibition of tumor growth (maximum tumor growth inhibition = 44%), which is alleviated upon cessation of dosing.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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