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  • 8-Nitrotryptanthrin
    货号: abs818310
    CAS号: 77603-42-0
    分子式: C15H7N3O4
    分子量: 293.23
    产品说明书
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    货号-规格 货期 价格 数量
    abs818310-1mg 1-2周 ¥1940.00
    - +
    abs818310-5mg 1-2周 ¥6174.00
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    大包装询价
    产品描述
    描述
    GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: 6.4 mg/mL (Need warming)
    生物活性
    靶点
    Indoleamine 2,3-Dioxygenase (IDO)
    In vitro(体外研究)
    The typtanthrin derivative 8-Nitrotryptanthrin (5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, especially, the compound 8-Nitrotryptanthrin demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). 8-Nitrotryptanthrin exhibits significant antitrypanosomal activity with EC50 of 0.82 μM. 8-Nitrotryptanthrin has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. 8-Nitrotryptanthrin also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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