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  • 7-Chlorokynurenic acid

    • 7-氯犬尿酸;7-氯-4-羟基喹啉-2-羧酸; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid;7-CKA
    货号: abs814939
    CAS号: 18000-24-3
    分子式: C10H6CINO3
    分子量: 223.62
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    货号-规格 货期 价格 数量
    abs814939-10mg 现货 ¥1048.00
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    abs814939-50mg 1-2周 ¥3859.00
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    大包装询价
    产品描述
    描述
    7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
    应用
    An NMDA receptor antagonist and inhibitor of EAAT
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    形态
    Solid
    基本信息
    别名
    7-氯犬尿酸;7-氯-4-羟基喹啉-2-羧酸; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid;7-CKA
    外观
    Off-white Solid
    IC50
    Glutamate NMDA receptor: IC50 = 320 nM (rat); Glutamate [NMDA] receptor subunit 3B: IC50 = 8 µM (rat)
    PK值
    pKa: 0.90 (Predicted), pKb: 9.79 (Predicted)
    Ki 数据
    Vesicular glutamate transporter 3: Ki= 590 µM (rat)
    可溶性/溶解性
    DMSO : 16.67 mg/mL (74.55 mM; Need ultrasonic)
    EC号码
    241-913-6
    生物活性
    靶点
    N-methyl-D-aspartate receptor
    reuptake of glutamate
    In vivo(体内研究)
    Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
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