7-Chlorokynurenic acid
- 7-氯犬尿酸；7-氯-4-羟基喹啉-2-羧酸; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid；7-CKA
货号： abs814939
| 货号-规格 | 货期 | 价格 | 数量 |
| abs814939-10mg | 现货 | ￥1048.00 | - + |
| abs814939-50mg | 1-2周 | ￥3859.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery. | |
| 应用 | An NMDA receptor antagonist and inhibitor of EAAT | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 形态 | Solid | |
| 基本信息 | ||
| 别名 | 7-氯犬尿酸；7-氯-4-羟基喹啉-2-羧酸; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid；7-CKA | |
| 外观 | Off-white Solid | |
| IC50 | Glutamate NMDA receptor: IC50 = 320 nM (rat); Glutamate [NMDA] receptor subunit 3B: IC50 = 8 µM (rat) | |
| PK值 | pKa: 0.90 (Predicted), pKb: 9.79 (Predicted) | |
| Ki 数据 | Vesicular glutamate transporter 3: Ki= 590 µM (rat) | |
| 可溶性/溶解性 | DMSO : 16.67 mg/mL (74.55 mM; Need ultrasonic) | |
| EC号码 | 241-913-6 | |
| 生物活性 | ||
| 靶点 | N-methyl-D-aspartate receptor
reuptake of glutamate | |
| In vivo(体内研究) | Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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Certificate of Analysis(COA)
