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  • 6-Mercaptopurine

    • 6-MP;Mercaptopurine
    货号: abs816461
    CAS号: 50-44-2
    分子式: C5H4N4S
    分子量: 152.18
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816461-5mg 1-2周 ¥475.00
    - +
    abs816461-10mg 1-2周 ¥617.00
    - +
    abs816461-100mg 1-2周 ¥710.00
    - +
    abs816461-500mg 1-2周 ¥1041.00
    - +
    大包装询价
    产品描述
    描述

    Mercaptopurine (6-mercaptopurine; 6-MP) is an immunosuppressive drug; is a thiopurine.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    6-MP;Mercaptopurine
    外观
    powder
    可溶性/溶解性
    DMSO:30mg/ml(197.13 mM)
    生物活性
    靶点
    PRPP Amidotransferase
    In vitro(体外研究)
    Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA . Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.
    In vivo(体内研究)
    In the fetal telencephalons of the 6-Mercaptopurine hydrate (6-MP)-treated group, the S phase cell population increases at 36 and 48 h and returns to the control level at 72 h after treatment. The G2/M phase cell population begins to increase at 24 h, peaks at 36 h, decreases at 48 h, and finally returnes to the control level at 72 h. On the other hand, the sub-G1 phase cell population (apoptotic cells) begins to increase at 36 h, peaks at 48 h, and then decreases at 72 h.
    参考文献
    参考文献
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