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  • 5-Iodotubercidin
  • 5-碘代杀结核菌素;7-去氮-7-碘代腺苷;NSC 113939;5-ITu
  • 货号: abs816236
    CAS号: 24386-93-4
    分子式: C11H13IN4O4
    分子量: 392.15
    产品说明书
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    货号-规格 货期 价格 数量
    abs816236-5mg 1-2周 ¥920.00
    - +
    abs816236-10mg 1-2周 ¥1655.00
    - +
    abs816236-25mg 1-2周 ¥3417.00
    - +
    大包装询价
    产品描述
    描述

    5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

    纯度
    99%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    5-碘代杀结核菌素;7-去氮-7-碘代腺苷;NSC 113939;5-ITu
    外观
    White to off-white powder
    可溶性/溶解性
    DMSO : 19.6 mg/mL (50 mM)
    生物活性
    靶点
    adenosine kinase
    In vitro(体外研究)
    5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms.
    In vivo(体内研究)
    5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain. 5-iodotubercidin has potent hypotensive, muscle relaxant, and hypothermic actions in mice, and that these effects could be blocked by theophylline, an adenosine receptor antagonist. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices.
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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