首页 产品中心
  • (R)-5-Hydroxymethyl Tolterodine
    • (R)-5-羟甲基托特罗定;Desfesoterodine;PNU-200577
    货号: abs816287
    CAS号: 207679-81-0
    分子式: C22H31NO2
    分子量: 341.49
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs816287-5mg 1-2周 ¥2170.00
    - +
    abs816287-10mg 1-2周 ¥3784.00
    - +
    大包装询价
    产品描述
    描述

    5-hydroxymethyl tolterodine是一种tolterodine的主要药理活性代谢物。5-hydroxymethyl tolterodine会竞争性抑制carbachol诱导的豚鼠离体膀胱条收缩,这种抑制具有浓度依特性。 5-hydroxymethyl tolterodine拮抗蕈毒碱受体 的pA2值为9.1。

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    中文别名
    (R)-5-羟甲基托特罗定;Desfesoterodine;PNU-200577
    外观
    淡黄色固体
    可溶性/溶解性
    Ethanol :63 mg/mL (184.5 mM)

    DMSO :63 mg/mL (184.5 mM)
    生物活性
    靶点
    mAChR
    In vitro(体外研究)
    5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. 5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure.
    In vivo(体内研究)
    5-hydroxymethyl tolterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more potent at the urinary bladder compared to the salivary gland.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要提问

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0