5'-Fluoroindirubinoxime
- 5'-FIO
货号: abs819772
货号-规格 | 货期 | 价格 | 数量 |
abs819772-10mg | 4周 | ¥2641.00 | - + |
abs819772-50mg | 4周 | ¥8254.00 | - + |

产品描述 | ||
描述 | 5’-Fluoroindirubinoxime is an antiproliferative agent and an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3). This compound has been shown to be selective for FMT3 against 6 other kinases including EGFR. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 5'-FIO | |
可溶性/溶解性 | DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic) | |
生物活性 | ||
In vitro(体外研究) | 5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively. 5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells. | |
In vivo(体内研究) | 5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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