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  • 4EGI-1
    货号: abs813459
    CAS号: 315706-13-9
    分子式: C18H12Cl2N4O4S
    分子量: 451.28
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs813459-5mg 1-2周 ¥1057.00
    - +
    abs813459-10mg 1-2周 ¥1377.00
    - +
    abs813459-25mg 1-2周 ¥2511.00
    - +
    abs813459-50mg 1-2周 ¥3645.00
    - +
    大包装询价
    产品描述
    描述

    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    可溶性/溶解性
    DMSO :45.1 mg/mL (100 mM)
    生物活性
    靶点
    Eukaryotic Initiation Factor (eIF)
    In vitro(体外研究)
    4EGI-1 is an inhibitor of eIF4E/eIF4G interaction, with a Kd of 25 μM against eIF4E binding. 4EGI-1 disrupts the eIF4F complex and inhibits expression of oncogenic proteins in mammalian cells. 4EGI-1 (0-40 μM) also exhibits proapoptotic activity and inhibits the growth of multiple cancer cell lines. 4EGI-1 is cytotoxic to breast cancer cells, such as SKBR-3, MCF-7 and MDA-MB-231 cells, with the IC50 of appr 30 μM, and to the non-CSCs (Cancer stem cells), the IC50 is about 22 μM. 4EGI-1 enhances breast CSC differentiation (40 μM), and suppresses breast CSC induced HUVEC tube-like structure formation (8 μM). Moreover, 4EGI-1 selectively inhibits translation that persists in CSC maintenance and dissemination. 4EGI-1 (50 µM) impairs the formation of eIF4F complex in U87 cells. 4EGI-1 (10, 50 and 100 µM) inhibits cell proliferation via inducing apoptosis in U87 cells, and the apoptosis is via Bax activation. 4EGI-1 causes mitochondrial dysfunction, and induces ER stress via GRP-78 activation, in U87 cells.
    In vivo(体内研究)
    4EGI-1 (75 mg/kg, i.p.) inhibits breast cancer stem cells (CSC) tumor growth and tumorangiogenesis in vivo. 4EGI-1 (75 mg/kg, i.p.) shows inhibitory effect on the tumor volume and weight in mice bearing U87 cells.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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