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  • 4E1rcat
    货号: abs810298
    CAS号: 328998-25-0
    分子式: C28H18N2O6
    分子量: 478.45
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810298-5mg 1-2周 ¥901.00
    - +
    abs810298-10mg 1-2周 ¥1433.00
    - +
    abs810298-50mg 1-2周 ¥3944.00
    - +
    abs810298-100mg 1-2周 ¥6195.00
    - +
    大包装询价
    产品描述
    描述

    4E1RCat is an inhibitor of protein translation that has been shown to prevent eIF4E:eIF4G and eIF4E:4E-BP1 interaction.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    外观
    褐色至深棕色粉末
    可溶性/溶解性
    DMSO : 23.9 mg/mL (50 mM)




    生物活性
    靶点
    Eukaryotic Initiation Factor (eIF)
    In vitro(体外研究)
    4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells.
    In vivo(体内研究)
    4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten+/-Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten+/-Eμ-Myc and Tsc2+/-Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice.
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