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  • 3-Chloro-5-hydroxybenzoic acid
  • 3-氯-5-羟基苯甲酸;3-chloro-5-hydroxy BA
  • 货号: abs814894
    CAS号: 53984-36-4
    分子式: C7H5ClO3
    分子量: 172.57
    产品说明书
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    货号-规格 货期 价格 数量
    abs814894-50mg 1-2周 ¥1418.00
    - +
    abs814894-100mg 1-2周 ¥2678.00
    - +
    大包装询价
    产品描述
    描述
    3-chloro-5-hydroxy BA is a GPR81 agonist.GPR81 (HCA1) is a member of G-protein-coupled receptors (GPCRs). GPR81 is predominantly expressed on adipocytes and is activated by the endogenous ligands 2-hydroxypropanoate (lactate). Stimulation of GPR81 in adipose tissue lead to a decrease in the lipolysis of triglycerides by hormone-sensitive lipase, which resulted in reduced transport of fatty acids to the liver and a decrease in hepatic triglycerides .
    纯度
    98%
    储存/保存方法
    Store at -20° C
    形态
    Solid
    基本信息
    别名
    3-氯-5-羟基苯甲酸;3-chloro-5-hydroxy BA
    外观
    white to beige powder
    可溶性/溶解性
    DMSO :34 mg/mL (197.02 mM)
    生物活性
    靶点
    GPR81
    In vitro(体外研究)
    In the hGPR81 assay, 3-chloro-5-hydroxybenzoic acid showed the potency against GPR81 with an EC50 of 16 μM. The EC50 of 3-chloro-5-hydroxybenzoic acid against monkey GPR81, dog GPR81, rat GPR81, mouse GPR81, and hamster GPR81 was 17 μM, 67 μM, 7 μM, 22 μM and 27 μM, respectively [1]. 3-chloro-5-hydroxy BA blocked basal ghrelin secretion by primary gastric mucosal cells.
    In vivo(体内研究)
    In mice, oral administration of 3-chloro-5-hydroxybenzoic acid at 30 mg/kg provided a Cmax of 67 μM at approximately 3-fold over the in vitro EC50 with an AUCinf of 54 h μM and a short t1/2 of 1.5 h, and the 100 mg/kg p.o dose attained a Cmax of 342 μM at greater than 15-fold over the observed in vitro EC50.
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