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  • 12-(S)-过氧化氢-5Z,8Z,10E,14Z-二十碳四烯酸

    • (12S)-12-Hydroperoxyicosa-5,8,10,14-Tetraenoic Acid
    货号: abs42003422
    CAS号: 71774-10-2
    分子式: C20H32O4
    分子量: 336.5
    产品说明书
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    货号-规格 货期 价格 数量
    abs42003422-25ug 6-8周 ¥2468.00
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    abs42003422-50ug 6-8周 ¥3990.00
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    大包装询价
    产品描述
    描述

    12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1.

    应用
    A fatty acid and an activator of human blood leukocyte 5-LO
    纯度
    ≥98%
    浓度
    50 µg/ml in ethanol
    储存/保存方法
    Store at -80° C
    形态
    Liquid
    基本信息
    沸点
    78° C
    折射率
    n20D 1.51
    IC50
    Ca2+-calmodulin-dependent protein kinase II: IC50 = 0.7 µM
    Ki 数据
    Endogenous TRPV1: Ki= 0.35 µM
    可溶性/溶解性
    Soluble in water (0.8 mg/ml at 25.0° C), DMSO, DMF, ethanol, pH 7.2 PBS (0.8 mg/ml), 0.1M Na2CO3 (2 mg/ml), and dimethyl formamide.
    PubChem CID
    656507
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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