12(R)-HEPE

12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus.¹ The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE (Catalog No. 34560).^2,3

≥98%

Store at -20℃

5,8,10,14,17-Eicosapentaenoicacid, 12-hydroxy-, [R-(E,Z,Z,Z,Z)]-

1.Hawkins, D.J. and Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. The Journal of Biological Chemisty 262, 7629-7634 (1987).

2.Masferrer, J.L.,Dunn, M.W. and Schwartzman, M.L. 12(R)-Hydroxyeicosatetraenoic acid, an endogenous corneal arachidonate metabolite, lowers intraocular pressure in rabbits. Investigative Ophthalmology & Visual Science 31, 535-539 (1990).

3.Conners, M.S.,Schwartzman, M.L.,Quan, X., et al. Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid. Journal of Investigative Dermatology 104, 47-51 (1995).