12-epi Leukotriene B4
- 12-epi LTB4
货号-规格 | 货期 | 价格 | 数量 |
abs42003439-25ug | 4周 | ¥2402.00 | - + |
abs42003439-50ug | 4周 | ¥4220.00 | - + |

产品描述 | ||
描述 | Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes, where the products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are racemic mixtures at C-12, but are nearly exclusive for trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced affinity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM), 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor. | |
应用 | A leukotriene with less affinity than LTB4 at LTB4 receptors | |
纯度 | 97% | |
浓度 | 0.1mg/ml | |
储存/保存方法 | Store at -20° C,1 year. | |
形态 | Liquid | |
基本信息 | ||
别名 | 12-epi LTB4 | |
外观 | solution in ethanol | |
沸点 | 78° C | |
可溶性/溶解性 | DMF : >50 mg/ml (per Rao Maddipati) DMSO : >50 mg/ml (per Rao Maddipati) Ethanol : >50 mg/ml (per Rao Maddipati) | |
PubChem CID | 169 | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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