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  • 12-epi Leukotriene B4

    • 12-epi LTB4
    货号: abs42003439
    CAS号: 83709-73-3
    分子式: C20H32O4
    分子量: 336.5
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    货号-规格 货期 价格 数量
    abs42003439-25ug 4周 ¥2402.00
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    abs42003439-50ug 4周 ¥4220.00
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    产品描述
    描述

    Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes, where the products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are racemic mixtures at C-12, but are nearly exclusive for trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced affinity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM), 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.

    应用
    A leukotriene with less affinity than LTB4 at LTB4 receptors
    纯度
    97%
    浓度
    0.1mg/ml
    储存/保存方法
    Store at -20° C,1 year.
    形态
    Liquid
    基本信息
    别名
    12-epi LTB4
    外观
    solution in ethanol
    沸点
    78° C
    可溶性/溶解性
    DMF : >50 mg/ml (per Rao Maddipati)
    DMSO : >50 mg/ml (per Rao Maddipati)
    Ethanol : >50 mg/ml (per Rao Maddipati)
    PubChem CID
    169
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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