11α-hydroxy Testosterone

11α-hydroxy Testosterone is a metabolite of testosterone, produced by the cytochrome P450 (CYP) isoform CYP3A.¹ It can also be generated from testosterone by a mutant of CYP107A1 and from 11α-hydroxy progesterone by the fungus B. bassiana.^2,3 The biological activity of this metabolite has not been elucidated.

≥97%

Store at 4℃

1.Zhao, Q. and Li, Z. Synthesis of 11-substituted androstenediones and testosterones as human decidual cell growth inhibitors. Steroids 59, 190-195 (1994).

2.Xiang, H.,Tschirret-Guth, R.A. and Ortiz de Montellano, P.R. An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. The Journal of Biological Chemisty 275(46), 35999-36006 (2000).

3.Swizdor, A.,Kolek, T.,Panek, A., et al. Microbial Baeyer-Villiger oxidation of steroidal ketones using Beauveria bassiana: Presence of an 11α-hydroxyl group essential to generation of D-homo lactones. Biochim.Biophys.Acta. 1811(4), 253-262 (2011).