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  • 11β-Prostaglandin F2α-d4
  • 9α,11β-PGF-d4;11β-PGF-d4;11-epi PGF-d4;
  • 货号: abs47044862
    CAS号: 1240398-18-8
    分子式: C20H30D4O5
    分子量: 358.5
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    货号-规格 货期 价格 数量
    abs47044862-100ug 4周 ¥3974.00
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    产品描述
    描述
    11β-Prostaglandin F-d4 (11β-PGF-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11β-PGF by GC- or LC-mass spectrometry. 11β-PGF is the primary plasma metabolite of PGD2 in vivo.1 Normal human urinary excretion of 11β-PGF is about 54 ng/mmol creatinine, which is increased nearly 3-fold upon allergen-induced bronchoconstriction in asthmatics.2 It is equipotent to PGF in inducing human bronchial smooth muscle contractions and inhibition of adipose differentiation.3,4 11β-PGF inhibits ADP or thrombin-induced human platelet aggregation at concentrations of 0.14 to 2.8 µM.5
    纯度
    ≥99% deuterated forms (d1-d4)
    储存/保存方法
    Store at -20℃
    基本信息
    别名
    9α,11β-PGF-d4;11β-PGF-d4;11-epi PGF-d4;
    参考文献
    参考文献
    1.Liston, T.E. and Roberts, L.J., II. Transformation of prostaglandin D2 to 9α,11β-(15S)-trihydroxy-prosta-(5Z,13E)-dien-1-oic acid (9α,11β-prostaglandin F2): A unique biologically active prostaglandin produced enzymatically in vivo in humans. Proceedings of the National Academy of Sciences of the United States of America 82, 6030-6034 (1985).

    2.O'Sullivan, S.,Dahlén, B.,Dahlén, S.E., et al. Increased urinary excretion of the prostaglandin D2 metabolite 9α,11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. Journal of Allergy and Clinical Immunology 98, 421-432 (1996).

    3.Coleman, R.A. and Sheldrick, R.L.G. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. British Journal of Pharmacology 96, 688-692 (1989).

    4.Lepak, N.M. and Serrero, G. Inhibition of adipose differentiation by 9α, 11β-prostaglandins F. Prostaglandins 46, 511-517 (1993).

    5.Pugliese, G.,Spokas, E.G.,Marcinkiewicz, E., et al. Hepatic transformation of prostaglandin D2 to a new prostanoid, 9α,11β-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. The Journal of Biological Chemisty 260, 14621-14625 (1985).

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