11β-Prostaglandin F2α-d4

11β-Prostaglandin F_2α-d₄ (11β-PGF_2α-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11β-PGF_2α by GC- or LC-mass spectrometry. 11β-PGF_2α is the primary plasma metabolite of PGD₂ in vivo.¹ Normal human urinary excretion of 11β-PGF_2α is about 54 ng/mmol creatinine, which is increased nearly 3-fold upon allergen-induced bronchoconstriction in asthmatics.² It is equipotent to PGF_2α in inducing human bronchial smooth muscle contractions and inhibition of adipose differentiation.^3,4 11β-PGF_2α inhibits ADP or thrombin-induced human platelet aggregation at concentrations of 0.14 to 2.8 µM.⁵

≥99% deuterated forms (d₁-d₄)

Store at -20℃

9α,11β-PGF_2α-d₄;11β-PGF_2α-d₄;11-epi PGF_2α-d₄;

1.Liston, T.E. and Roberts, L.J., II. Transformation of prostaglandin D₂ to 9α,11β-(15S)-trihydroxy-prosta-(5Z,13E)-dien-1-oic acid (9α,11β-prostaglandin F2): A unique biologically active prostaglandin produced enzymatically in vivo in humans. Proceedings of the National Academy of Sciences of the United States of America 82, 6030-6034 (1985).

2.O'Sullivan, S.,Dahlén, B.,Dahlén, S.E., et al. Increased urinary excretion of the prostaglandin D₂ metabolite 9α,11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. Journal of Allergy and Clinical Immunology 98, 421-432 (1996).

3.Coleman, R.A. and Sheldrick, R.L.G. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. British Journal of Pharmacology 96, 688-692 (1989).

4.Lepak, N.M. and Serrero, G. Inhibition of adipose differentiation by 9α, 11β-prostaglandins F_2α. Prostaglandins 46, 511-517 (1993).

5.Pugliese, G.,Spokas, E.G.,Marcinkiewicz, E., et al. Hepatic transformation of prostaglandin D₂ to a new prostanoid, 9α,11β-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. The Journal of Biological Chemisty 260, 14621-14625 (1985).