11-酮氟前列醇

11-keto Fluprostenol is an analog of prostaglandin D₂ (PGD₂) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF_2α and acts primarily through the FP receptor.¹ Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP₂ receptor compared to PGD₂ and essentially no activity at the DP₁ receptor.²

≥98%

Store at -20℃

1.Dukes, M.,Russell, W. and Walpole, A.L. Potent luteolytic agents related to prostaglandin F_2α. Nature 250, 330-331 (1974).

2.Monneret, G.,Cossette, C.,Gravel, S., et al. 15R-methyl-prostaglandin D₂ is a potent and selective CRTH2/DP₂ receptor agonist in human eosinophils. Journal of Pharmacology and Experimental Therapeutics 304(1), 349-355 (2003).