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  • (±)11(12)-EpETE
  • (±)11,12-EEQ;(±)11,12-Epoxyeicosatetraenoic Acid;
  • 货号: abs47045855
    CAS号: 504435-15-8
    分子式: C20H30O3
    分子量: 318.5
    产品说明书
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    货号-规格 货期 价格 数量
    abs47045855-100ug 4周 ¥4220.00
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    产品描述
    描述
    Eicosapentaenoic acid (EPA; Item No. 90110) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms.1 The major product of this epoxygenase pathway, (±)17(18)-EpETE (Item No. 50861), relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits.2,3,4 (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.1,5 The biological actions and physiological effects of this epoxide remain to be determined.
    纯度
    ≥98%
    储存/保存方法
    Store at -20℃
    基本信息
    别名
    (±)11,12-EEQ;(±)11,12-Epoxyeicosatetraenoic Acid;
    参考文献
    参考文献
    1.Barbosa-Sicard, E.,Markovic, M.,Honeck, H., et al. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Biochemical and Biophysical Research Communications 329, 1275-1281 (2005).

    2.Lauterbach, B.,Barbosa-Sicard, E.,Wang, M.H., et al. Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39, 609-613 (2002).

    3.Hercule, H.C.,Salanova, B.,Essin, K., et al. The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BKα channel subunit in rodents. Experimental Physiology 92(6), 1067-1076 (2007).

    4.Morin, C.,Sirois, M.,Echave, V., et al. Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung. American Journal of Physiology.Lung Cellular and Molecular Physiology 296, L130-L139 (2009).

    5.Arnold, C.,Markovic, M.,Blossey, K., et al. Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of omega-3 fatty acids. The Journal of Biological Chemisty 285, 32720-32733 (2010).

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