Eicosapentaenoic acid (EPA; Item No. 90110) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms.¹ The major product of this epoxygenase pathway, (±)17(18)-EpETE (Item No. 50861), relaxes vascular and airway smooth muscle by binding large conductance Ca²⁺-activated K⁺ (BK_Ca) channels by directly interacting with BKα channel subunits.^2,3,4 (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.^1,5 The biological actions and physiological effects of this epoxide remain to be determined.

≥98%

Store at -20℃

(±)11,12-EEQ;(±)11,12-Epoxyeicosatetraenoic Acid;

1.Barbosa-Sicard, E.,Markovic, M.,Honeck, H., et al. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Biochemical and Biophysical Research Communications 329, 1275-1281 (2005).

2.Lauterbach, B.,Barbosa-Sicard, E.,Wang, M.H., et al. Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39, 609-613 (2002).

3.Hercule, H.C.,Salanova, B.,Essin, K., et al. The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BKα channel subunit in rodents. Experimental Physiology 92(6), 1067-1076 (2007).

4.Morin, C.,Sirois, M.,Echave, V., et al. Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung. American Journal of Physiology.Lung Cellular and Molecular Physiology 296, L130-L139 (2009).

5.Arnold, C.,Markovic, M.,Blossey, K., et al. Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of omega-3 fatty acids. The Journal of Biological Chemisty 285, 32720-32733 (2010).