11-脱氧前列腺素 e1

11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1 . Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC₅₀ of 0.25 μM. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The K_i values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.

An agonist of EP2, EP3, and EP4

≥96%

Store at -20° C

Solid

Crystalline

~1.1 g/cm³ (Predicted)

194.60° C (Predicted)

~509.7° C at 760 mmHg (Predicted)

Soluble in PBS (~1.6 mg/ml), ethanol (~50 mg/ml), DMSO (~50 mg/ml), and DMF (~100 mg/ml).

5283055