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  • 11-deoxy-11-methylene-15-keto Prostaglandin D2
  • 11-deoxy-11-methylene-15-keto PGD2;
  • 货号: abs47046291
    CAS号: 958759-75-6
    分子式: C21H32O4
    分子量: 348.5
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    货号-规格 货期 价格 数量
    abs47046291-1mg 4周 ¥11828.00
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    产品描述
    描述
    Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
    纯度
    ≥98%
    储存/保存方法
    Store at -20℃
    基本信息
    别名
    11-deoxy-11-methylene-15-keto PGD2;
    参考文献
    参考文献
    1.Boie, Y.,Sawyer, N.,Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270, 18910-18916 (1995).

    2.Gervais, F.G.,Cruz, R.,Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. Journal of Allergy and Clinical Immunology 108(6), 982-988 (2002).

    3.Monneret, G.,Gravel, S.,Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98(6), 1942-1948 (2001).

    4.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001).

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