11-deoxy-11-methylene-15-keto Prostaglandin D2

Prostaglandin D₂ (PGD₂) is one of the five primary enzymatic prostaglandins derived directly from PGH₂. Many of the biological effects of PGD₂ are transduced in vivo by a classical 7-transmembrane GPCR, the DP₁ receptor.¹ However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD₂.^2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD₂ metabolite 13,14-dihydro-15-keto PGD₂.⁴ 11-deoxy-11-methylene-15-keto PGD₂ was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD₂.

≥98%

Store at -20℃

11-deoxy-11-methylene-15-keto PGD₂;

1.Boie, Y.,Sawyer, N.,Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270, 18910-18916 (1995).

2.Gervais, F.G.,Cruz, R.,Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD₂ receptors CRTH2 and DP. Journal of Allergy and Clinical Immunology 108(6), 982-988 (2002).

3.Monneret, G.,Gravel, S.,Diamond, M., et al. Prostaglandin D₂ is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98(6), 1942-1948 (2001).

4.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D₂ selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001).