(5Z,13E,15R)-15-羟基-16,16-二甲基-9-氧代-前列腺-5,13-二烯-1-酸

11-deoxy-16,16-dimethyl Prostaglandin E2 is a stable synthetic analog of PGE2 , that has been shown to act as a selective agonist for both EP2 and EP3 receptors, unlike PGE2 which agonizes a variety of prostanoid receptors. This compound has shown effective inhibition of gastric acid secretion and ulcer formation in the rat, with ED₅₀ values of 1 mg/kg and 0.021 mg/kg, respectively, and is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.

An analog of PGE2 shown to act as a selective agonist for EP2 & EP3 receptors

>98%

Store at -20° C

Liquid

11-Deoxy-16,16-dimethyl-PGE2;15-Hydroxy-16,16-dimethyl-9-oxoprosta-5,13-dienoic acid; AY 24609

57° C

n²⁰_D 1.54 (Predicted)

Soluble in water (>5 mg/ml at 25° C), PBS (pH 7.2) (~5 mg/ml), ethanol (~100 mg/ml), DMSO (~100 mg/ml), and DMF (~100 mg/ml).

MFCD00135216

3246818