10-Thiastearic Acid

Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.^1,2 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.³ This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

≥98%

Store at -20℃

1.Wu, P.,Grav, H.J.,Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochemical Pharmacology 51, 751-758 (1996).

2.Pascal, R.A., Jr. and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. Journal of Lipid Research 27, 221-224 (1986).

3.Hovik, K.E.,Spydevold, O.S. and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochimica et Biophysica Acta 1349, 251-256 (1997).